Lexicon Pharmaceuticals received FDA approval to market its heart failure drug Inpefa, as well as a broad label compared to rivals like AstraZeneca's Farxiga and Lilly's Jardiance. The FDA gave Inpefa a pretty broad label that I believe will help with the challenges of marketing the drug against entrenched rivals - the label was perhaps not all that investors may have wished for, but was still good on balance. Heaviness. Merriam-Webster.com Thesaurus, Merriam-Webster, https://www.merriam-webster.com/thesaurus/heaviness. He vouchsafed no explanation, and Clem, though, Little wonder that we returned after two years of terrible privation, empty-handed and. "They've started to understand they have to push further into the dictionary," says Shourav Dasari, a 20-year-old former speller and a co-founder with his older sister Shobha of SpellPundit, which sells study guides and hosts a popular online bee. Now that the drug is approved, it's at least plausible that larger pharmaceutical companies could come knocking on Lexicon's door. Place names, trademarks, words with no language of origin: As long as a word isn't archaic or obsolete, it's fair game. There were no specified limitations on use, nor any contraindications beyond the standard hypersensitivity contraindication (the familiar "don't use X if you are allergic to X" that you hear all the time in drug ads). Best synonyms for 'heaviness of heart' are 'heartbreak', 'heavy heart' and 'abasement'. Though Foo Fighters' drummer will be replaced on tour by Josh Freese, Grohl returns to the kit throughout the new record, and he brings raw, instantly identifiable intensity to its 10 tracks. English Standard Version Anxiety in a man's heart weighs him down, but a good word makes him glad. "Last year, we started seeing stuff like tribal names that are some of the hardest words in the dictionary.". This site allows you to find in one place, all the synonyms and antonyms of the English language. 2. Accessed 2 Jun. To see more, visit https://www.npr.org. If it takes 10 years to get to 10% share, the value of Inpefa would be somewhere in the range of $4. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body. The current collaborative approach didn't take shape until the early '90s. phrases. Synonyms for 'Heaviness of heart'. Accessed 2 Jun. Lists. Copyright 2023 KTRK-TV. The department received the call at about 5:30 a.m. about a two-alarm fire. It happened at the Co-Cathedral of the Sacred Heart on St. Joseph Parkway. If you have an ad-blocker enabled you may be blocked from proceeding. Show all Definitions . "Nice word, but bye-bye," pronouncer Kevin Moch says. Proverbs 17:22 A merry heart doeth good like a medicine: but a broken spirit drieth the bones. HOUSTON Officials with Houston Fire Department said heavy smoke inside a downtown-area church prompted a two-alarm fire response Friday morning. I think Lexicon Pharmaceuticals, Inc. is a worthwhile name for very aggressive investors, but visions of revenue upside ought to be tempered by the realities of the challenges of competing with some of the largest fish in the pharma ocean. Toggle navigation. Absent head-to-head studies, I'm reluctant to say that Inpefa is clearly superior (though there seems to be a bigger gap with Jardiance than Farxiga), but the data do seem to trend that way for at least some of the metrics. Heavy Heart Meaning What Does "Heavy Heart" Mean? And as they got smarter and smarter, they got more in contact with each other and were studying off the same lists, it became harder to hold a bee with those same types of words," Trinkle says. I continue to believe that Lexicon Pharmaceuticals, Inc. remains a high-risk proposition. Random Heaviness of heart synonyms What is another wordfor Heaviness of heart? The band's 11th studio album, But Here We Are, is out now. 2. Grohl clearly understands that we honor departed loved ones by building new joys we wish they were around to share. If you need help with the Public File, call (713) 778-4745. Words with similar meaning of Heaviness of heart at Thesaurus dictionary Synonym.tech. Synonyms of heavy 1 a : having great weight also : characterized by mass or weight how heavy is it? Foo Fighters formed in the aftermath of tragedy, as Kurt Cobain 's 1994 suicide left Dave Grohl reeling and in search of a voice. Remains of nine saints, including American Elizabeth Ann Seton and Leo the Great, help fill the space. Still, all the talk of death that pervades But Here We Are shouldn't overshadow what a truly formidable rock record it is so catchy and vibrant, so brimming with wild-eyed wonder. A synonym is a word, adjective, verb or expression that has the same meaning as another, or almost the same meaning. Roget's 21st Century Thesaurus, Third Edition Copyright 2013 by the Philip Lief Group. 2018 Synonyms-thesaurus.com - All rights reserved. The Jardiance studies weren't structured exactly the same, but delivered HRs of 0.69 and 0.70 for HHF and first/recurrent HHFs in E-REDUCED and 0.71 and 0.73 in E-PRESERVED. King James Bible Foo Fighters perform in Gilford, N.H. on May 24. Synonyms for HEAVY HEART: aching heart, agony of mind, bathos, bleeding-heart, broken-heart, heartache, heaviness of heart, pathos, sad heart. the numbers on the back of each sample indicate the, the backpack was filled with water bottles that gave it an extra, Post more words for heaviness to Facebook, Share more words for heaviness on Twitter, Palter, Dissemble, and Other Words for Lying, Skunk, Bayou, and Other Words with Native American Origins, Words For Things You Didn't Know Have Names, Vol. Jun . The process seemed to go smoothly through the 2010s, even amid a proliferation of so-called "minor league" bees, many catering to offspring of highly educated, first-generation Indian immigrants a group that has come to dominate the competition. Firefighters placed a ladder and hoses up on the east side of the building. sorrow despair heaviness of heart and sorrow heavyheartedness despair heaviness of heart and heavyheartedness distress despair heaviness of heart and distress Moreover, this comes without any meaningful issues on the tolerability or safety side. Nglish: Translation of heaviness for Spanish Speakers, Britannica English: Translation of heaviness for Arabic Speakers. rainy day. Heartache and Heaviness of heart are synonymous, and they have mutual synonyms. Foo Fighters perform in Gilford, N.H. on May 24. Each word has been vetted by the panel and slotted into the appropriate round of the nearly century-old annual competition to identify the English language's best speller. You can use "Cheerlessness" instead a noun phrase "Heaviness of heart". Synonym Dictionary; Antonym Dictionary; Idiom, Proverb; English Stories . Officials with Houston Fire Department said heavy smoke inside a downtown-area church prompted a two-alarm fire response Friday morning. Need a better saying than Heaviness Of Heart? (Most of the time.). Since the bee resumed after its 2020 pandemic cancellation, the panel has been scrutinized largely for the vocabulary questions, which have added a capricious element, knocking out some of the most gifted spellers even if they don't misspell a word. On the minus side, there's a lot of expensive work left to be done if Lexicon is going to capture enough market share to make the drug meaningfully profitable. thesaurus. For E-REDUCED and E-PRESERVED, Jardiance showed an 8% and 9% risk reduction, while for Farxiga, DECLARE showed a 2% risk reduction, DAPA-CKD showed a 19% risk reduction, DAPA-HF an 18% risk reduction, and DELIVER a 12% reduction. Synonyms of heaviness heaviness noun Definition of heaviness 1 as in weight the amount that something weighs the numbers on the back of each sample indicate the heaviness of the carpeting material Synonyms & Similar Words Relevance weight heft avoirdupois bulk tonnage solidity poundage massiveness weightiness ponderousness mass deadweight solidness Before panelists can debate the words picked for the bee, they need to hear each word and its language of origin, part of speech, definition and exemplary sentence read aloud. despair . To save this word, you'll need to log in. That's what happened late in Sunday's meeting. START THE QUIZ SYNONYM OF THE DAY Likewise, I could see a buyout in the high single-digits to low double-digits depending upon what Lexicon can achieve in terms of early uptake. Copyright 2023 NPR. By the time of this gathering, two days before the bee, the word list is all but complete. "Harvey made the whole list," Bailly says. Find 31 ways to say HEAVY-HEARTED, along with antonyms, related words, and example sentences at Thesaurus.com, the world's most trusted free thesaurus. This avoids repetitions in a sentence without changing its meaning. For all its hard-driving abandon, "Under You" taps into a deep well of sentiment "Someone said I'll never see your face again / Part of me just can't believe it's true / Pictures of us share sharing songs and cigarettes / This is how I'll always picture you" as it contemplates grief as both a great weight and a process. - . suggest new. Says a Servian proverb, "Give me a comrade who will weep with me; one who will laugh I can easily find." Hearing the words aloud with the entire panel present laptops open to Merriam-Webster's Unabridged dictionary sometimes illuminates problems. By about 6:30 a.m., SkyEye video shows no active flames or smoke, but firefighters were seen entering the church at 1115 St. Joseph Parkway. Foo Fighters formed in the aftermath of tragedy, as Kurt Cobain 's 1994 suicide left . Of course, Lexicon may not go it alone forever. weighty suggests having actual and not just relative weight. ", "They are fun and challenging for me and they make me smile, and I know if I was a speller I would be intimidated by that word," says the 28-year-old Mishra, who just finished his MBA at Harvard. The panel was created in 1985. Proverbs 15:23 A man hath joy by the answer of his mouth: and a word spoken in due season, how good is it! definitions. The 21 panelists sit around a makeshift, rectangular conference table in a windowless room tucked inside the convention center outside Washington where the bee is staged every year. The band's 11th studio album, But Here We Are, is out now. Foo Fighters formed in the aftermath of tragedy, as Kurt Cobain 's 1994 suicide left . 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